3-異丁基-1-甲基黃嘌呤,Santa IBMX ,CAS 28822-58-4

產(chǎn)品名稱：3-異丁基-1-甲基黃嘌呤

英文名稱：IBMX

同義詞：3-Isobutyl-1-methylanxthine; Methylisobutylxanthine; MIX

品牌：Santa CRUZ

貨號：sc-201188

CAS號：28822-58-4

純度：≥99%

分子量大小：222.24

分子式：C10H14N4O2

規(guī)格：200 mg和1 g

貨期：2周

特惠價格：致電咨詢

英文描述：

IBMX is one of the most potent and nonspecific inhibitors of cyclic nucleotide PDE (phosphodiesterases) with documented IC50 values for PDE1, 2, 3, 4, and 5 equaling 19, 50, 18, 13 and 32. The compound is documented to raise intracellular cyclic AMP levels. In rat sensory neurons the addition of IBMX caused the release of Ca2+ from caffeine ryanodine sensitive internal stores increasing the internal Ca2+ levels and inducing a biphasic membrane current response. Through PDE inhibition IBMX has also inhibited TNFα. IBMX in breast cancer cells has also induced p21 and p27 through a PKA independent pathway. Although a nonspecific PDE inhibitor IBMX does not show inhibition of PDE8B. In neuroendocrine epithelial cells IBMX has been observed to inhibit α-adrenoceptor-mediated 5-HT release at IC50 = 1.3μM.

技術(shù)信息：

物理狀態(tài)：Solid

溶解度：Soluble in ethanol (10 mg/ml), DMSO(with gentle warming) (1 M), methanol(warm) (50 mg/ml), 2-propanol, dichloromethane, ether, ethyl acetate, and DMF (~5 mg/ml). Insoluble in water.

存儲：Store at room temperature

熔點：200-201 °C (lit.)

沸點：445.6 °C at 760 mmHg (Predicted)

濃度：1.3 g/cm3 (Predicted)

折射率：n20D 1.57 (Predicted)

IC50: suppresses α-adrenoceptor-mediated 5-HT release: IC50 = 1.3 μM (neuroendocrine epithelial cells); PDE4: IC50 = 13 μM; PDE3: IC50 = 18 μM; PDE1: IC50 = 19 μM; PDE5 : IC50 = 32 μM; PDE2: IC50 = 50 μM; Phosphodiesterase 1B: IC50 = 100 nM (rat); Sodium channel protein type II alpha subunit: IC50 = 1800 nM (human)

Ki數(shù)據(jù)：Adenosine A2b receptor: Ki= 50 nM (rat); Adenosine A2a receptor: Ki= 800 nM (rat); Adenosine A1 receptor: Ki= 2000 nM (rat)

pK值：pKa: 8.61 (Predicted), pKb: 1.49 (Predicted)

注意：本產(chǎn)品僅供科研使用。不可用于診斷或治療。